"... provocative and rewarding... " --Religious Studies Review "... a tour de force." --Theological Studies Theology and Difference reconceives the options confronting modern theology and investigates the disputed questions that underlie it. Pressing beyond the ready-made enlightenment offered by the subject-object framework, Walter Lowe uncovers a number of remarkable convergences between the contemporary philosopher Jacques Derrida and the early twentieth-century theologian Karl Barth.

When does a person qualify for protected and continuing life? At a time when technology can sustain marginal life, it is ever more important to understand what constitutes a person.

Most important, James W. Walters compares and contrasts Buber's and feminism's personalist ethics in light of two considerations: the lack of attention by ...

Are humans free, or are we determined by our genes and the world around us? The question of freedom is not only one of philosophy’s greatest conundrums, but also one of the most fundamental questions of human existence. It’s particularly pressing in societies like ours, where our core institutions of law, ethics, and religion are built around the belief in individual freedom. Can one still affirm human freedom in an age of science? And if free will doesn’t exist, does it (...) make sense to act as though it does? These are the issues that are presented, probed, and debated in the following chapters. A dozen experts―specialists in medicine, psychology, ethics, theology, and philosophy—grapple with the multiple and often profound challenges presented by today’s brain science. After examining the arguments against traditional notions of free will, several of the authors champion the idea of a chastened but robust free will for today, one that allows us still to affirm the value of first-person experience. (shrink)

Gene therapy approaches have great promise in the treatment of neurodegenerative disorders and malignant brain tumors. Neuwelt et al. review available viral-mediated gene therapy methods and their blood-brain-barrier (BBB) disruption delivery technique, briefly mentioning nonviral mediated gene therapy methods. This commentary discussed the BBB disruption delivery technique, viral and nonviral mediated gene therapy approaches to Parkinson's disease, and the potential use of antisense oligo to suppress malignant brain tumors.

In his extensive work as a theologian and a historian, Walter H. Principe, CSB, (1922-1996) was committed to reflecting on both the present and the past. He was well-known as an historian of medieval theology and philosophy - especially through the work of Thomas Aquinas, as well as a contemporary theologian. This memorial collection addresses a fundamental feature of Principe's thought, namely his concern that the history of medieval theology and philosophy have a significant role to play in contemporary (...) discussions. Strengthening the ties between historical study and contemporary theological and philosophical thought, this book offers much to those who teach and research in historical theology and the history of philosophy. The ten essays provide significant test cases of how modern scholars may utilise the historical record judiciously for contemporary debates. Those who are concerned with intellectual history (both medieval and modern), the history of doctrines, and Thomism will also find this collection a useful contribution to modern scholarship. (shrink)

In this paper, rather than focusing on genes as an organising concept around which historical considerations of theory and practice in genetics are elucidated, we place genetic markers at the heart of our analysis. This reflects their central role in the subject of our account, livestock genetics concerning the domesticated pig, Sus scrofa. We define a genetic marker as a element existing in different forms in the genome, that can be identified and mapped using a variety of quantitative, classical and (...) molecular genetic techniques. The conjugation of pig genome researchers around the common object of the marker from the early-1990s allowed the distinctive theories and approaches of quantitative and molecular genetics concerning the size and distribution of gene effects to align in projects to populate genome maps. Critical to this was the nature of markers as ontologically inert, internally heterogeneous and relational. Though genes as an organising and categorising principle remained important, the particular concatenation of limitations, opportunities, and intended research goals of the pig genetics community, meant that a progressively stronger focus on the identification and mapping of markers rather than genes per se became a hallmark of the community. We therefore detail a different way of doing genetics to more gene-centred accounts. By doing so, we reveal the presence of practices, concepts and communities that would otherwise be hidden. (shrink)

This paper assesses the effect of DNA barcoding—the use of informative genetic markers to identify and discriminate between species—on taxonomy. Throughout, we interpret this in terms of _varipraxis_, a concept we introduce to make sense of the treatment of biological variation by scientists and other practitioners. From its inception, DNA barcoding was criticised for being reductive, in attempting to replace multiple forms of taxonomic evidence with just one: DNA sequence variation in one or a few indicative genes. We show, though, (...) how DNA barcoding has not narrowed or reduced taxonomy in the way it was projected to. We examine the development and implementation of DNA barcoding across three kingdoms of life: animals, plants, and protists. Through this, we demonstrate that for DNA barcoding to work, the range of acceptable intra-specific variation needs to be demarcated from variation deemed to be characteristic of inter-specific differences. Consequently, biological processes responsible for particular patterns of variation need to be investigated and understood. This encourages an integrative disposition towards understanding and explaining the evolutionary processes affecting the rate and nature of change at the nucleotide level. We detail how the impact of DNA barcoding has manifested differently across the three kingdoms we examine, assessing this in terms of the ontological commitments that are held and instantiated in practice. Based on this evaluation, we consider the problem of studying multi-kingdom communities, and assess the consequences of our analysis for understanding classification and taxonomy. (shrink)

This paper aims to clarify the consequences of new scientific and philosophical approaches for the practical-theoretical framework of modern developmental biology. I highlight normal development, and the instructive-permissive distinction, as key parts of this framework which shape how variation is conceptualised and managed. Furthermore, I establish the different dimensions of biological variation: the units, temporality and mode of variation. Using the analytical frame established by this, I interpret a selection of examples as challenges to the instructive-permissive distinction. These examples include (...) the phenomena of developmental plasticity and transdifferentiation, the role of the microbiome in development, and new methodological approaches to standardisation and the assessment of causes. Furthermore, I argue that investigations into organismal development should investigate the effects of a wider range of kinds of variation including variation in the units, modes and temporalities of development. I close by examining various possible opportunities for producing and using normal development free of the assumptions of the instructive-permissive distinction. These opportunities are afforded by recent developments, which include new ways of producing standards incorporating more natural variation and being based on function rather than structure, and the ability to produce, store, and process large quantities of data. (shrink)

Biologists who work on the pig (_Sus scrofa_) take advantage of its similarity to humans by constructing the inferential and material means to traffic data, information and knowledge across the species barrier. Their research has been funded due to its perceived value for agriculture and medicine. Improving selective breeding practices, for instance, has been a driver of genomics research. The pig is also an animal model for biomedical research and practice, and is proposed as a source of organs for cross-species (...) transplantation: xenotransplantation. Genomics research has informed transplantation biology, which has itself motivated developments in genomics. Both have generated models of correspondences between the genomes of pigs and humans. Concerning genomics, I detail how researchers traverse species boundaries to develop representations of the pig genome, alongside ensuring that such representations are sufficiently porcine. In transplantation biology, the representations of the genomes of humans and pigs are used to detect and investigate immunologically-pertinent differences between the two species. These key differences can then be removed, to ‘humanise’ donor pigs so that they can become a safe and effective source of organs. In both of these endeavours, there is a tension between practices that ‘humanise’ the pig (or representations thereof) through using resources from human genomics, and the need to ‘dehumanise’ the pig to maintain distinctions for legal, ethical and scientific reasons. This paper assesses the ways in which this tension has been managed, observing the differences between its realisations across comparative pig genomics and transplantation biology, and considering the consequences of this. (shrink)

In the present research, we qualitatively document the process by which spiritual leader and leadership emerge in religion-based organizations. Data from 26 participants in three religion-based organizations revealed three cardinal themes that depict the development of spiritual leader and spiritual leadership, the process of developing a spiritual leader and spiritual leadership, and outcomes of spiritual leader and leadership development. Based on the results, we propose a model that depicts the phases involved in the development of spiritual leader/leadership in the religion-based (...) workplace. These phases are proposed to impact the outcomes for the leader, followers, and the organization. The implications of our results are discussed. (shrink)

American Continental Philosophy is the first anthology to gather a representative selection of the most important and original thinkers from the continental tradition in the U.S. The essays reflect the diverse directions and methodologies that have emerged from this influential field. This state-of-the-art sampler showcases the richness and scope of American continental philosophy and will be of value to the entire philosophical community.

We investigate the relationship between two approaches to modeling physical systems. On the first approach, simplifying assumptions are made about the level of detail we choose to represent in a computational simulation with an eye toward tractability. On the second approach simpler, analogue physical systems are considered that have more or less well-defined connections to systems of interest that are themselves too difficult to probe experimentally. Our interest here is in the connections between the artifacts of modeling that appear in (...) these two approaches. We begin by outlining an important respect in which the two are essentially dissimilar and then propose a method whereby overcoming that dissimilarity by hand results in usefully analogous behavior. We claim that progress can be made if we think of artifacts as clues to the projectible predicates proper to the models themselves. Our degree of control over the connection between interesting analogue physical systems and their targets arises from determining the projectible predicates in the analogue system through a combination of theory and experiment. To obtain a similar degree of control over the connection between large-scale, distributed simulations of complex systems and their targets we must similarly determine the projectible predicates of the simulations themselves. In general theory will be too intractable to be of use, and so we advocate an experimental program for determining these predicates. the object of the natural history which I propose is...to give light to the discovery of causes and supply a suckling philosophy with its first food . Francis Bacon, The Great Instauration. (shrink)